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Computer-Assisted Classification Patterns in Autoimmune Diagnostics: The AIDA Project

Identifieur interne : 000322 ( Main/Exploration ); précédent : 000321; suivant : 000323

Computer-Assisted Classification Patterns in Autoimmune Diagnostics: The AIDA Project

Auteurs : Amel Benammar Elgaaied [Tunisie] ; Donato Cascio [Italie] ; Salvatore Bruno [Italie] ; Maria Cristina Ciaccio [Italie] ; Marco Cipolla [Italie] ; Alessandro Fauci [Italie] ; Rossella Morgante [Italie] ; Vincenzo Taormina [Italie] ; Yousr Gorgi [Tunisie] ; Raja Marrakchi Triki [Tunisie] ; Melika Ben Ahmed [Tunisie] ; Hechmi Louzir [Tunisie] ; Sadok Yalaoui [Tunisie] ; Sfar Imene [Tunisie] ; Yassine Issaoui [Tunisie] ; Ahmed Abidi [Tunisie] ; Myriam Ammar [Tunisie] ; Walid Bedhiafi [Tunisie] ; Oussama Ben Fraj [Tunisie] ; Rym Bouhaha [Tunisie] ; Khouloud Hamdi [Tunisie] ; Koudhi Soumaya [Tunisie] ; Bilel Neili [Tunisie] ; Gati Asma [Tunisie] ; Mariano Lucchese [Italie] ; Maria Catanzaro [Italie] ; Vincenza Barbara [Italie] ; Ignazio Brusca [Italie] ; Maria Fregapane [Italie] ; Gaetano Amato [Italie] ; Giuseppe Friscia [Italie] ; Trai Neila [Tunisie] ; Souayeh Turkia [Tunisie] ; Haouami Youssra [Tunisie] ; Raja Rekik [Tunisie] ; Hayet Bouokez [Tunisie] ; Maria Vasile Simone [Italie] ; Francesco Fauci [Italie] ; Giuseppe Raso [Italie]

Source :

BioMed Research International [ 2314-6133 ] ; 2016.

RBID : PMC:4794569

Descripteurs français

KwdFr :
- Anticorps antinucléaires (immunologie), Anticorps antinucléaires (isolement et purification), Humains (MeSH), Italie (MeSH), Maladies auto-immunes (anatomopathologie), Maladies auto-immunes (imagerie diagnostique), Maladies auto-immunes (immunologie), Technique d'immunofluorescence indirecte (MeSH), Traitement d'image par ordinateur (méthodes), Tunisie (MeSH).
MESH :
- anatomopathologie : Maladies auto-immunes.
- imagerie diagnostique : Maladies auto-immunes.
- immunologie : Anticorps antinucléaires, Maladies auto-immunes.
- isolement et purification : Anticorps antinucléaires.
- méthodes : Traitement d'image par ordinateur.
- Humains, Italie, Technique d'immunofluorescence indirecte, Tunisie.

English descriptors

KwdEn :
- Antibodies, Antinuclear (immunology), Antibodies, Antinuclear (isolation & purification), Autoimmune Diseases (diagnostic imaging), Autoimmune Diseases (immunology), Autoimmune Diseases (pathology), Fluorescent Antibody Technique, Indirect (MeSH), Humans (MeSH), Image Processing, Computer-Assisted (methods), Italy (MeSH), Tunisia (MeSH).
MESH :
- chemical , immunology : Antibodies, Antinuclear.
- chemical , isolation & purification : Antibodies, Antinuclear.
- diagnostic imaging : Autoimmune Diseases.
- immunology : Autoimmune Diseases.
- methods : Image Processing, Computer-Assisted.
- pathology : Autoimmune Diseases.
- Fluorescent Antibody Technique, Indirect, Humans, Italy, Tunisia.

Abstract

Antinuclear antibodies (ANAs) are significant biomarkers in the diagnosis of autoimmune diseases in humans, done by mean of Indirect ImmunoFluorescence (IIF) method, and performed by analyzing patterns and fluorescence intensity. This paper introduces the AIDA Project (autoimmunity: diagnosis assisted by computer) developed in the framework of an Italy-Tunisia cross-border cooperation and its preliminary results. A database of interpreted IIF images is being collected through the exchange of images and double reporting and a Gold Standard database, containing around 1000 double reported images, has been settled. The Gold Standard database is used for optimization of a CAD (Computer Aided Detection) solution and for the assessment of its added value, in order to be applied along with an Immunologist as a second Reader in detection of autoantibodies. This CAD system is able to identify on IIF images the fluorescence intensity and the fluorescence pattern. Preliminary results show that CAD, used as second Reader, appeared to perform better than Junior Immunologists and hence may significantly improve their efficacy; compared with two Junior Immunologists, the CAD system showed higher Intensity Accuracy (85,5% versus 66,0% and 66,0%), higher Patterns Accuracy (79,3% versus 48,0% and 66,2%), and higher Mean Class Accuracy (79,4% versus 56,7% and 64.2%).

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794569

DOI: 10.1155/2016/2073076
PubMed: 27042658
PubMed Central: 4794569

Affiliations:

Italie, Tunisie

Le document en format XML

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<author><name sortKey="Ben Ahmed, Melika" sort="Ben Ahmed, Melika" uniqKey="Ben Ahmed M" first="Melika" last="Ben Ahmed">Melika Ben Ahmed</name>
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<author><name sortKey="Friscia, Giuseppe" sort="Friscia, Giuseppe" uniqKey="Friscia G" first="Giuseppe" last="Friscia">Giuseppe Friscia</name>
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<author><name sortKey="Neila, Trai" sort="Neila, Trai" uniqKey="Neila T" first="Trai" last="Neila">Trai Neila</name>
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<author><name sortKey="Youssra, Haouami" sort="Youssra, Haouami" uniqKey="Youssra H" first="Haouami" last="Youssra">Haouami Youssra</name>
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<author><name sortKey="Rekik, Raja" sort="Rekik, Raja" uniqKey="Rekik R" first="Raja" last="Rekik">Raja Rekik</name>
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<author><name sortKey="Bouokez, Hayet" sort="Bouokez, Hayet" uniqKey="Bouokez H" first="Hayet" last="Bouokez">Hayet Bouokez</name>
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<author><name sortKey="Vasile Simone, Maria" sort="Vasile Simone, Maria" uniqKey="Vasile Simone M" first="Maria" last="Vasile Simone">Maria Vasile Simone</name>
<affiliation wicri:level="1"><nlm:aff id="I10">CyclopusCAD srl, 90128 Palermo, Italy</nlm:aff>
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<author><name sortKey="Fauci, Francesco" sort="Fauci, Francesco" uniqKey="Fauci F" first="Francesco" last="Fauci">Francesco Fauci</name>
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<author><name sortKey="Raso, Giuseppe" sort="Raso, Giuseppe" uniqKey="Raso G" first="Giuseppe" last="Raso">Giuseppe Raso</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Computer-Assisted Classification Patterns in Autoimmune Diagnostics: The AIDA Project</title>
<author><name sortKey="Benammar Elgaaied, Amel" sort="Benammar Elgaaied, Amel" uniqKey="Benammar Elgaaied A" first="Amel" last="Benammar Elgaaied">Amel Benammar Elgaaied</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cascio, Donato" sort="Cascio, Donato" uniqKey="Cascio D" first="Donato" last="Cascio">Donato Cascio</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Dipartimento di Fisica e Chimica, Università Degli Studi di Palermo, 90128 Palermo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Fisica e Chimica, Università Degli Studi di Palermo, 90128 Palermo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bruno, Salvatore" sort="Bruno, Salvatore" uniqKey="Bruno S" first="Salvatore" last="Bruno">Salvatore Bruno</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Dipartimento di Fisica e Chimica, Università Degli Studi di Palermo, 90128 Palermo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Fisica e Chimica, Università Degli Studi di Palermo, 90128 Palermo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ciaccio, Maria Cristina" sort="Ciaccio, Maria Cristina" uniqKey="Ciaccio M" first="Maria Cristina" last="Ciaccio">Maria Cristina Ciaccio</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Dipartimento di Fisica e Chimica, Università Degli Studi di Palermo, 90128 Palermo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Fisica e Chimica, Università Degli Studi di Palermo, 90128 Palermo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cipolla, Marco" sort="Cipolla, Marco" uniqKey="Cipolla M" first="Marco" last="Cipolla">Marco Cipolla</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Dipartimento di Fisica e Chimica, Università Degli Studi di Palermo, 90128 Palermo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Fisica e Chimica, Università Degli Studi di Palermo, 90128 Palermo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fauci, Alessandro" sort="Fauci, Alessandro" uniqKey="Fauci A" first="Alessandro" last="Fauci">Alessandro Fauci</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Dipartimento di Fisica e Chimica, Università Degli Studi di Palermo, 90128 Palermo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Fisica e Chimica, Università Degli Studi di Palermo, 90128 Palermo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Morgante, Rossella" sort="Morgante, Rossella" uniqKey="Morgante R" first="Rossella" last="Morgante">Rossella Morgante</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Dipartimento di Fisica e Chimica, Università Degli Studi di Palermo, 90128 Palermo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Fisica e Chimica, Università Degli Studi di Palermo, 90128 Palermo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Taormina, Vincenzo" sort="Taormina, Vincenzo" uniqKey="Taormina V" first="Vincenzo" last="Taormina">Vincenzo Taormina</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Dipartimento di Fisica e Chimica, Università Degli Studi di Palermo, 90128 Palermo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Fisica e Chimica, Università Degli Studi di Palermo, 90128 Palermo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gorgi, Yousr" sort="Gorgi, Yousr" uniqKey="Gorgi Y" first="Yousr" last="Gorgi">Yousr Gorgi</name>
<affiliation wicri:level="1"><nlm:aff id="I3">Hôpital Charles Nicolle, 1006 Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Hôpital Charles Nicolle, 1006 Tunis</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Marrakchi Triki, Raja" sort="Marrakchi Triki, Raja" uniqKey="Marrakchi Triki R" first="Raja" last="Marrakchi Triki">Raja Marrakchi Triki</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ben Ahmed, Melika" sort="Ben Ahmed, Melika" uniqKey="Ben Ahmed M" first="Melika" last="Ben Ahmed">Melika Ben Ahmed</name>
<affiliation wicri:level="1"><nlm:aff id="I4">Institut Pasteur, 1002 Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Institut Pasteur, 1002 Tunis</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Louzir, Hechmi" sort="Louzir, Hechmi" uniqKey="Louzir H" first="Hechmi" last="Louzir">Hechmi Louzir</name>
<affiliation wicri:level="1"><nlm:aff id="I4">Institut Pasteur, 1002 Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Institut Pasteur, 1002 Tunis</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yalaoui, Sadok" sort="Yalaoui, Sadok" uniqKey="Yalaoui S" first="Sadok" last="Yalaoui">Sadok Yalaoui</name>
<affiliation wicri:level="1"><nlm:aff id="I5">Hôpital Ariana, 2080 Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Hôpital Ariana, 2080 Tunis</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Imene, Sfar" sort="Imene, Sfar" uniqKey="Imene S" first="Sfar" last="Imene">Sfar Imene</name>
<affiliation wicri:level="1"><nlm:aff id="I3">Hôpital Charles Nicolle, 1006 Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Hôpital Charles Nicolle, 1006 Tunis</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Issaoui, Yassine" sort="Issaoui, Yassine" uniqKey="Issaoui Y" first="Yassine" last="Issaoui">Yassine Issaoui</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Abidi, Ahmed" sort="Abidi, Ahmed" uniqKey="Abidi A" first="Ahmed" last="Abidi">Ahmed Abidi</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ammar, Myriam" sort="Ammar, Myriam" uniqKey="Ammar M" first="Myriam" last="Ammar">Myriam Ammar</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bedhiafi, Walid" sort="Bedhiafi, Walid" uniqKey="Bedhiafi W" first="Walid" last="Bedhiafi">Walid Bedhiafi</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ben Fraj, Oussama" sort="Ben Fraj, Oussama" uniqKey="Ben Fraj O" first="Oussama" last="Ben Fraj">Oussama Ben Fraj</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bouhaha, Rym" sort="Bouhaha, Rym" uniqKey="Bouhaha R" first="Rym" last="Bouhaha">Rym Bouhaha</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hamdi, Khouloud" sort="Hamdi, Khouloud" uniqKey="Hamdi K" first="Khouloud" last="Hamdi">Khouloud Hamdi</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Soumaya, Koudhi" sort="Soumaya, Koudhi" uniqKey="Soumaya K" first="Koudhi" last="Soumaya">Koudhi Soumaya</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Neili, Bilel" sort="Neili, Bilel" uniqKey="Neili B" first="Bilel" last="Neili">Bilel Neili</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Asma, Gati" sort="Asma, Gati" uniqKey="Asma G" first="Gati" last="Asma">Gati Asma</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Faculté des Sciences, Université de Tunis El Manar, 1088 Tunis</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lucchese, Mariano" sort="Lucchese, Mariano" uniqKey="Lucchese M" first="Mariano" last="Lucchese">Mariano Lucchese</name>
<affiliation wicri:level="1"><nlm:aff id="I6">Ospedale S. Antonio Abate, 91016 Trapani, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Ospedale S. Antonio Abate, 91016 Trapani</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Catanzaro, Maria" sort="Catanzaro, Maria" uniqKey="Catanzaro M" first="Maria" last="Catanzaro">Maria Catanzaro</name>
<affiliation wicri:level="1"><nlm:aff id="I6">Ospedale S. Antonio Abate, 91016 Trapani, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Ospedale S. Antonio Abate, 91016 Trapani</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Barbara, Vincenza" sort="Barbara, Vincenza" uniqKey="Barbara V" first="Vincenza" last="Barbara">Vincenza Barbara</name>
<affiliation wicri:level="1"><nlm:aff id="I6">Ospedale S. Antonio Abate, 91016 Trapani, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Ospedale S. Antonio Abate, 91016 Trapani</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brusca, Ignazio" sort="Brusca, Ignazio" uniqKey="Brusca I" first="Ignazio" last="Brusca">Ignazio Brusca</name>
<affiliation wicri:level="1"><nlm:aff id="I7">Ospedale Buccheri La Ferla Fatebenefratelli, 90123 Palermo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Ospedale Buccheri La Ferla Fatebenefratelli, 90123 Palermo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fregapane, Maria" sort="Fregapane, Maria" uniqKey="Fregapane M" first="Maria" last="Fregapane">Maria Fregapane</name>
<affiliation wicri:level="1"><nlm:aff id="I7">Ospedale Buccheri La Ferla Fatebenefratelli, 90123 Palermo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Ospedale Buccheri La Ferla Fatebenefratelli, 90123 Palermo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Amato, Gaetano" sort="Amato, Gaetano" uniqKey="Amato G" first="Gaetano" last="Amato">Gaetano Amato</name>
<affiliation wicri:level="1"><nlm:aff id="I8">Ospedale Civico, 90121 Palermo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Ospedale Civico, 90121 Palermo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Friscia, Giuseppe" sort="Friscia, Giuseppe" uniqKey="Friscia G" first="Giuseppe" last="Friscia">Giuseppe Friscia</name>
<affiliation wicri:level="1"><nlm:aff id="I9">Ospedale di Sciacca, 92019 Agrigento, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Ospedale di Sciacca, 92019 Agrigento</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Neila, Trai" sort="Neila, Trai" uniqKey="Neila T" first="Trai" last="Neila">Trai Neila</name>
<affiliation wicri:level="1"><nlm:aff id="I3">Hôpital Charles Nicolle, 1006 Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Hôpital Charles Nicolle, 1006 Tunis</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Turkia, Souayeh" sort="Turkia, Souayeh" uniqKey="Turkia S" first="Souayeh" last="Turkia">Souayeh Turkia</name>
<affiliation wicri:level="1"><nlm:aff id="I3">Hôpital Charles Nicolle, 1006 Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Hôpital Charles Nicolle, 1006 Tunis</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Youssra, Haouami" sort="Youssra, Haouami" uniqKey="Youssra H" first="Haouami" last="Youssra">Haouami Youssra</name>
<affiliation wicri:level="1"><nlm:aff id="I3">Hôpital Charles Nicolle, 1006 Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Hôpital Charles Nicolle, 1006 Tunis</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rekik, Raja" sort="Rekik, Raja" uniqKey="Rekik R" first="Raja" last="Rekik">Raja Rekik</name>
<affiliation wicri:level="1"><nlm:aff id="I4">Institut Pasteur, 1002 Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Institut Pasteur, 1002 Tunis</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bouokez, Hayet" sort="Bouokez, Hayet" uniqKey="Bouokez H" first="Hayet" last="Bouokez">Hayet Bouokez</name>
<affiliation wicri:level="1"><nlm:aff id="I5">Hôpital Ariana, 2080 Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Hôpital Ariana, 2080 Tunis</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vasile Simone, Maria" sort="Vasile Simone, Maria" uniqKey="Vasile Simone M" first="Maria" last="Vasile Simone">Maria Vasile Simone</name>
<affiliation wicri:level="1"><nlm:aff id="I10">CyclopusCAD srl, 90128 Palermo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>CyclopusCAD srl, 90128 Palermo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fauci, Francesco" sort="Fauci, Francesco" uniqKey="Fauci F" first="Francesco" last="Fauci">Francesco Fauci</name>
<affiliation wicri:level="1"><nlm:aff id="I10">CyclopusCAD srl, 90128 Palermo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>CyclopusCAD srl, 90128 Palermo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Raso, Giuseppe" sort="Raso, Giuseppe" uniqKey="Raso G" first="Giuseppe" last="Raso">Giuseppe Raso</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Dipartimento di Fisica e Chimica, Università Degli Studi di Palermo, 90128 Palermo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Fisica e Chimica, Università Degli Studi di Palermo, 90128 Palermo</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">BioMed Research International</title>
<idno type="ISSN">2314-6133</idno>
<idno type="eISSN">2314-6141</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Antinuclear (immunology)</term>
<term>Antibodies, Antinuclear (isolation & purification)</term>
<term>Autoimmune Diseases (diagnostic imaging)</term>
<term>Autoimmune Diseases (immunology)</term>
<term>Autoimmune Diseases (pathology)</term>
<term>Fluorescent Antibody Technique, Indirect (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Image Processing, Computer-Assisted (methods)</term>
<term>Italy (MeSH)</term>
<term>Tunisia (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps antinucléaires (immunologie)</term>
<term>Anticorps antinucléaires (isolement et purification)</term>
<term>Humains (MeSH)</term>
<term>Italie (MeSH)</term>
<term>Maladies auto-immunes (anatomopathologie)</term>
<term>Maladies auto-immunes (imagerie diagnostique)</term>
<term>Maladies auto-immunes (immunologie)</term>
<term>Technique d'immunofluorescence indirecte (MeSH)</term>
<term>Traitement d'image par ordinateur (méthodes)</term>
<term>Tunisie (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Antinuclear</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antibodies, Antinuclear</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Maladies auto-immunes</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Autoimmune Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Maladies auto-immunes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antinucléaires</term>
<term>Maladies auto-immunes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Autoimmune Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Anticorps antinucléaires</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Image Processing, Computer-Assisted</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Traitement d'image par ordinateur</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Autoimmune Diseases</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Fluorescent Antibody Technique, Indirect</term>
<term>Humans</term>
<term>Italy</term>
<term>Tunisia</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Humains</term>
<term>Italie</term>
<term>Technique d'immunofluorescence indirecte</term>
<term>Tunisie</term>
</keywords>
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<front><div type="abstract" xml:lang="en"><p>Antinuclear antibodies (ANAs) are significant biomarkers in the diagnosis of autoimmune diseases in humans, done by mean of Indirect ImmunoFluorescence (IIF) method, and performed by analyzing patterns and fluorescence intensity. This paper introduces the AIDA Project (autoimmunity: diagnosis assisted by computer) developed in the framework of an Italy-Tunisia cross-border cooperation and its preliminary results. A database of interpreted IIF images is being collected through the exchange of images and double reporting and a Gold Standard database, containing around 1000 double reported images, has been settled. The Gold Standard database is used for optimization of a CAD (Computer Aided Detection) solution and for the assessment of its added value, in order to be applied along with an Immunologist as a second Reader in detection of autoantibodies. This CAD system is able to identify on IIF images the fluorescence intensity and the fluorescence pattern. Preliminary results show that CAD, used as second Reader, appeared to perform better than Junior Immunologists and hence may significantly improve their efficacy; compared with two Junior Immunologists, the CAD system showed higher Intensity Accuracy (85,5% versus 66,0% and 66,0%), higher Patterns Accuracy (79,3% versus 48,0% and 66,2%), and higher Mean Class Accuracy (79,4% versus 56,7% and 64.2%).</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fritzler, M J" uniqKey="Fritzler M">M. J. Fritzler</name>
</author>
</analytic>
</biblStruct>
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</author>
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</author>
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<author><name sortKey="Platzgummer, S" uniqKey="Platzgummer S">S. Platzgummer</name>
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<author><name sortKey="Damoiseaux, J" uniqKey="Damoiseaux J">J. Damoiseaux</name>
</author>
<author><name sortKey="Kallenberg, C" uniqKey="Kallenberg C">C. Kallenberg</name>
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</analytic>
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<biblStruct><analytic><author><name sortKey="Hiemann, R" uniqKey="Hiemann R">R. Hiemann</name>
</author>
<author><name sortKey="Buttner, T" uniqKey="Buttner T">T. Büttner</name>
</author>
<author><name sortKey="Krieger, T" uniqKey="Krieger T">T. Krieger</name>
</author>
<author><name sortKey="Roggenbuck, D" uniqKey="Roggenbuck D">D. Roggenbuck</name>
</author>
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</author>
<author><name sortKey="Conrad, K" uniqKey="Conrad K">K. Conrad</name>
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</analytic>
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</author>
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</author>
<author><name sortKey="Peters, V" uniqKey="Peters V">V. Peters</name>
</author>
</analytic>
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</author>
<author><name sortKey="Bellotti, R" uniqKey="Bellotti R">R. Bellotti</name>
</author>
<author><name sortKey="De Carlo, F" uniqKey="De Carlo F">F. De Carlo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ciatto, S" uniqKey="Ciatto S">S. Ciatto</name>
</author>
<author><name sortKey="Cascio, D" uniqKey="Cascio D">D. Cascio</name>
</author>
<author><name sortKey="Fauci, F" uniqKey="Fauci F">F. Fauci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cascio, D" uniqKey="Cascio D">D. Cascio</name>
</author>
<author><name sortKey="Fauci, F" uniqKey="Fauci F">F. Fauci</name>
</author>
<author><name sortKey="Iacomi, M" uniqKey="Iacomi M">M. Iacomi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rigon, A" uniqKey="Rigon A">A. Rigon</name>
</author>
<author><name sortKey="Buzzulini, F" uniqKey="Buzzulini F">F. Buzzulini</name>
</author>
<author><name sortKey="Soda, P" uniqKey="Soda P">P. Soda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cohen, J" uniqKey="Cohen J">J. Cohen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cascio, D" uniqKey="Cascio D">D. Cascio</name>
</author>
<author><name sortKey="Magro, R" uniqKey="Magro R">R. Magro</name>
</author>
<author><name sortKey="Fauci, F" uniqKey="Fauci F">F. Fauci</name>
</author>
<author><name sortKey="Iacomi, M" uniqKey="Iacomi M">M. Iacomi</name>
</author>
<author><name sortKey="Raso, G" uniqKey="Raso G">G. Raso</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vivona, L" uniqKey="Vivona L">L. Vivona</name>
</author>
<author><name sortKey="Cascio, D" uniqKey="Cascio D">D. Cascio</name>
</author>
<author><name sortKey="Fauci, F" uniqKey="Fauci F">F. Fauci</name>
</author>
<author><name sortKey="Raso, G" uniqKey="Raso G">G. Raso</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Iacomi, M" uniqKey="Iacomi M">M. Iacomi</name>
</author>
<author><name sortKey="Cascio, D" uniqKey="Cascio D">D. Cascio</name>
</author>
<author><name sortKey="Fauci, F" uniqKey="Fauci F">F. Fauci</name>
</author>
<author><name sortKey="Raso, G" uniqKey="Raso G">G. Raso</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fauci, F" uniqKey="Fauci F">F. Fauci</name>
</author>
<author><name sortKey="La Manna, A" uniqKey="La Manna A">A. La Manna</name>
</author>
<author><name sortKey="Cascio, D" uniqKey="Cascio D">D. Cascio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cascio, D" uniqKey="Cascio D">D. Cascio</name>
</author>
<author><name sortKey="Taormina, V" uniqKey="Taormina V">V. Taormina</name>
</author>
<author><name sortKey="Cipolla, M" uniqKey="Cipolla M">M. Cipolla</name>
</author>
<author><name sortKey="Fauci, F" uniqKey="Fauci F">F. Fauci</name>
</author>
<author><name sortKey="Vasile, M" uniqKey="Vasile M">M. Vasile</name>
</author>
<author><name sortKey="Raso, G" uniqKey="Raso G">G. Raso</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cascio, D" uniqKey="Cascio D">D. Cascio</name>
</author>
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</author>
<author><name sortKey="Magro, R" uniqKey="Magro R">R. Magro</name>
</author>
<author><name sortKey="Raso, G" uniqKey="Raso G">G. Raso</name>
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</analytic>
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</author>
<author><name sortKey="Fauci, F" uniqKey="Fauci F">F. Fauci</name>
</author>
<author><name sortKey="Raso, G" uniqKey="Raso G">G. Raso</name>
</author>
</analytic>
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<author><name sortKey="Dhaouadi, T" uniqKey="Dhaouadi T">T. Dhaouadi</name>
</author>
<author><name sortKey="Sfar, I" uniqKey="Sfar I">I. Sfar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bradwell, A" uniqKey="Bradwell A">A. Bradwell</name>
</author>
<author><name sortKey="Stokes, R" uniqKey="Stokes R">R. Stokes</name>
</author>
<author><name sortKey="Johnson, G" uniqKey="Johnson G">G. Johnson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Furnkranz, J" uniqKey="Furnkranz J">J. Furnkranz</name>
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</analytic>
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<author><name sortKey="Tangaro, S" uniqKey="Tangaro S">S. Tangaro</name>
</author>
<author><name sortKey="Golosio, B" uniqKey="Golosio B">B. Golosio</name>
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<author><name sortKey="Cascio, D" uniqKey="Cascio D">D. Cascio</name>
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<author><name sortKey="Magro, R" uniqKey="Magro R">R. Magro</name>
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<author><name sortKey="Fauci, F" uniqKey="Fauci F">F. Fauci</name>
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<author><name sortKey="Raso, G" uniqKey="Raso G">G. Raso</name>
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<author><name sortKey="Bruno, S" uniqKey="Bruno S">S. Bruno</name>
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Computer-Assisted Classification Patterns in Autoimmune Diagnostics: The AIDA Project

Computer-Assisted Classification Patterns in Autoimmune Diagnostics: The AIDA Project

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